Cutaneous Metastasis of Choriocarcinoma

Vol. 27, No. 6, 2015 793 Received August 9, 2014, Revised February 15, 2015, Accepted for publication March 21, 2015 Corresponding author: Sung Ku Ahn, Department of Dermatology, Yonsei University Wonju College of Medicine, 20 Ilsan-ro, Wonju 26426, Korea. Tel: 82-33-741-0621, Fax: 82-33-748-2650, E-mail: [email protected] This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Fig. 1. A solitary bean-sized oval reddish nodule on the vertex of the scalp. Fig. 2. Marked red blood cell extravasation and dermal infiltration of anaplastic malignant tumor cells. Cytotrophoblastic cells (yellow arrow) with a polygonal clear cytoplasm and large vesicular nuclei with prominent nucleoli, and syncytiotrophoblastic cells (red arrow) with hyperchromatic nuclei and an eosinophillic cytoplasm are seen (H&E, ×200). Immunohistochemical staining of the cytoplasm of syncytiotrophoblasts against the human chorionic gonadotropin (hCG) antigen shows a strong positive reaction (inset; ×200). http://dx.doi.org/10.5021/ad.2015.27.6.793